Sunderland and Republic of Ireland midfielder Graham Kavanagh is to have knee surgery that could keep him on the sidelines for six weeks.
Kavanagh joined from Wigan for £500,000
A scan showed the 32-year-old has cartilage damage and will undergo an operation on Thursday.
It means he will miss the Republic of Ireland's Euro 2008 qualifiers against Cyprus and Czech Republic.
Kavanagh has been a big success at Sunderland since arriving from Wigan on transfer deadline day.
Sunderland boss Roy Keane said: "He faces four to six weeks out and it's another disappointment for us, they are dropping like flies at the moment.
"Graham was struggling with his knee in the second half at Ipswich so we just needed to get it done.
"I'd rather have a fit and strong Graham Kavanagh than one struggling with a knee injury."
The Black Cats already have Steven Wright, Steve Caldwell, Stephen Elliott, David Connolly and Daryl Murphy ruled out of action through injury.