Defender Hermann Hreidarsson and striker Danny Webber have been ruled out for six months with long-term injuries, while midfielder Jamie O'Hara is also unlikely to feature under the terms of his loan deal from Spurs.
Striker Aruna Dindane is unavailable because another appearance will trigger a payment to Lens which Portsmouth cannot afford.
Marc Wilson, Nadir Belhadj, Papa Bouba Diop, Kevin-Prince Boateng, Tal Ben-Haim and Hassan Yebda are all doubtful for the lucrative match.
Owusu-Abeyie scored one goal in 11 appearances for Portsmouth this season.
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