Portsmouth pair Lomana LuaLua and Patrick Berger are unlikely to play again this season.
Berger's season looks to have come to an early end
Both players picked up injuries during the 4-1 victory over local rivals Southampton two weeks ago.
Striker LuaLua was forced to limp out of the game with a hamstring injury and midfielder Berger suffered a badly bruised ankle.
Pompey play Bolton at Fratton Park on Saturday and finish off their season with an away match against West Brom.