Northampton defender Ashley Westwood is set to play his first game of the season in the reserves on Tuesday.
Westwood has not played for Northampton since April
Westwood, 29, has been sidelined since damaging knee ligaments in April.
The ex-Crewe and Sheffield Wednesday centre-back has been dogged by injuries since joining Northampton in July 2003, but is set to face Oxford's reserves.
Striker Martin Smith is set to ply as he looks to improve match fitness after playing his first game of the season in Saturday's draw with Darlington.