United, who are seeking a fourth consecutive Premier League title, only have two games remaining this season, at Sunderland on 2 May and when Stoke visit Old Trafford a week later.
England play Mexico in a friendly on 24 May at Wembley, then against Japan in another friendly in Graz in Austria on 30 May, with their first World Cup match on 12 June against the USA in Rustenburg.
Ryan Giggs scored two penalties in Saturday's win over Spurs, which returned United to the top of the table on 79 points, two ahead of second-placed Chelsea, who have a game in hand and host Stoke on Sunday.
After playing Stoke, Chelsea travel to Liverpool, and host Wigan on the last day of the season.
Rooney, favourite to win the PFA player of the year award on Sunday night, is not the only injury concern for United and England.
Captain Rio Ferdinand missed his second consecutive match, also with a groin injury, after a season plagued by back problems.
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