The former West Ham and Leeds defender had previously identified the match against Spurs, who are top of the Premier League, as the likeliest target for his comeback.
United have been hit by several injuries to defenders in the early stages of the season, with Ferdinand's regular centre-back partner Nemanja Vidic missing the first two games of the season because of a calf injury before returning to the fray.
Jonny Evans was forced to come off before the end of the victories over Birmingham and Wigan as he continues to feel the effects of a long-standing ankle problem.
And the international break has supplied Ferguson with another injury to contend with after John O'Shea picked up a calf injury while on duty with the Republic of Ireland.
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