The leading surgeon has previously operated on former Newcastle striker Alan Shearer, new United signing Michael Owen and ex-Red Devils forward Ruud van Nistelrooy, who is now at Real Madrid.
Hargreaves, who has only started 25 times for his club since a £17m move from Bayern Munich in July 2007, had been expected to rejoin the United squad in August, but was forced to delay his comeback. However, Ferguson is confident the England international will return in good shape as he continues his rehabilitation with the club.
"The difficult part will be to get him back into the football side," added the Scot.
"We are certain his fitness will be good and his endurance work will have been done but you don't have a player who has been out for over a year and suddenly throw him back into the fire right away."
Canadian-born Hargreaves last played for United in the 1-1 draw with Chelsea on 21 September 2008.
His condition, patellar tendinitis, can be described as inflammation of the tendon that attaches the quadriceps (thigh muscle) to the tibia (shin bone).
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