It means Bellamy faces a race against time before Wales' next World Cup qualifying double-header with Finland and Germany.
John Toshack's team play Finland in Cardiff on 28 March before Group Four leaders Germany visit the Millennium Stadium four days later.
But Bellamy, whose career has been plagued by knee injuries and who required career-saving knee reconstruction, is set to miss four crucial games for his club, including a UEFA Cup last-16 tie with Aalborg.
"Since he came to the club he has carried the fight for us," stated Hughes.
"Against a team like Villa you need as many of your top players available as possible."
Robinho, meanwhile, damaged ligaments in his ankle at Upton Park but Hughes is hopeful the Brazilian will return for their European fixture.
Bulgaria striker Valeri Bojinov is set to continue his return from injury with a place on the substitutes' bench against Villa in the Premier League.
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