Doncaster Rovers forward James Coppinger and midfielder Brian Stock have both been ruled out for the rest of the season.
Stock, 27, has a persistent back problem while 28-year-old Coppinger has an injured Achilles tendon.
"It's difficult to bring in like for like because they are two influential players," manager Sean O'Driscoll told BBC Radio Sheffield.
Rovers currently lie 15th in the Championship with six games remaining.
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