Jewell will get funds to strengthen his squad during the summer
American ownership of Premier League clubs has received mixed reactions in English football since the Glazer family took over Manchester United three years ago.
Their arrival initially prompted protests among the Old Trafford faithful, while Tom Hicks and George Gillett's control of Liverpool continues to attract controversy.
However, Randy Lerner's regime at Aston Villa has rejuvinated the Midlands club and proved that investment from across the pond can reap rewards.
Derby, the latest club to look to the States for a cash injection, will hope that General Sports and Entertainment (GSE) can achieve similar success and revitalise the club heading towards the Championship.
BBC Radio Five Live's Pat Murphy, who has closely followed developments at Derby, assesses the Andy Appleby-led £50m takeover of the Premier League strugglers.
WHO ARE GSE?
A sports entertainment company operating out of Detroit, Michigan, fronted by founder and president Appleby who has 21 years working in sports management.
GSE will be banking on Derby coming straight back up to the Premier League
BBC Radio Five Live's Pat Murphy
They specialise in American sports management, ie American football, baseball, basketball and hockey, and own clubs across that sporting spectrum.
The attraction to Derby for them was the global brand of the Premier League, and Appleby wants to secure a global brand for his company.
The worldwide exposure the Premier League receives is the attraction, and it's not surprising that he is following the Glazers, Hicks and Gillett and Lerner.
They're going provide money to spend and a create a stable infrastructure which hasn't always been the case at Derby in recent years.
Jewell is the seventh manager since 2001 so it's been a club that has been known for it's instability both in football terms and financial matters also. But putting that in the past, it could prove to be a seminal day for the club.
DID THE THREAT OF RELEGATION DETER GSE?
That scenario is in the uppermost of their minds, but it's fair to say that £50m isn't a bad price for a Premier League club, albeit one that's clinging to the wreckage.
But it's still going to be in the top flight for another three-and-a-half months where they can get the exposure around the world of playing Arsenal, Manchester United and Liverpool.
They will make substantial sums available to Jewell in the summer to buy new players so they will be banking on coming straight back up again.
I would guess that in 18 months time, if Derby are back in the Premier League, Derby will be worth a lot more than £50m, so there is a long-term plan too.
WHAT IS GSE'S LONG-TERM VISION FOR DERBY?
The club feel Appleby, who has run his own company for the last 10 years and is steeped in public relations expertise, knows what is needed to sell a club to a community.
They are very keen on the Lerner model where you come in, sign a cheque, wipe off the debt and start from that base with no caveats of a financial nature.
The club are very bullish about this and they believe the evolution at Villa will be emulated at Derby.
WILL THE TAKEOVER MEAN A LATE FLURRY OF TRANSFERS?
Jewell is absolutely delighted by the sea change. He has already met Appleby and spoke to him on the phone on several occasions and has been reassured there will be a reasonable amount of money available for new players.
Pearson's pitch to GSE has paid off for Derby
But Jewell has already said that it would be irresponsible to buy players now, given that they are in freefall and they are likely to be relegated.
However, he will do a lot of work in the summer when the transfer window re-opens where he will be given substantial funds to strengthen the squad.
IS PAUL JEWELL'S POSITION SAFE?
Safe as houses. There is no problem at all about Jewell's tenure, it is not, as I understand it, like the way Rafael Benitez has been destabilised at Liverpool.
There's not going to be the pressure on Jewell because the club have got low expectations. Jewell wants to look at the club from top to bottom and is looking for a root-and-branch evolution, and he will be given time.
WHO WILL ACTUALLY RUN THE CLUB?
Pearson will remain in a senior capacity and this has been a triumph for him, while Appleby will stay in America.
Pearson will have an important role in the new set-up, and he has done fantastically well to secure this deal. He would be a sound choice to carry on and see it through.
I understand that he, Jewell and Appleby will be the key players in the operation.