Brian Tinnion has stepped down as Bristol City manager following long discussions with chairman Steve Lansdown on Sunday afternoon.
Brian Tinnion had been in charge at Ashton Gate for 15 months
The move came after the 7-1 thrashing at Swansea on Saturday which left City in the League One relegation zone.
Assistant manager Keith Millen has been made caretaker boss and is in charge while the permanent post is advertised.
Former City player Tinnion took charge at Ashton Gate in the summer of 2004 after Danny Wilson's departure.
Lansdown said he accepted Tinnion's decision, telling City's website: "I fully understand his frustration at recent results and the pressure that has been placed upon him and his family.
"During his time as manager he has worked tirelessly on all aspects at the football club, in the first team and the development of our younger players.
"I would like to wish Brian all the best for his future career."
Millen also paid tribute to Tinnion, telling the website: "I am very disappointed Brian has decided to stand down.
"He was instrumental in my appointment as assistant manager and it's been a pleasure working with him.
"I would like to place on record my thanks to him and I'm just sorry it hasn't worked out for him at the club.
"The chairman told me he would be happy for me to apply for the post but it's too early to reply on that front."