Bees boss Martin Allen is ringing the changes at Griffin Park
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Brentford have told Welsh midfielder Stephen Evans that he will not be offered a new contract this summer.
Alan Julian, Jay Smith and Dean Wells are also being allowed to leave.
On-loan trio Joel Kitamirike (Chelsea), Ben May (Millwall) and Tommy Wright (Leicester) will all be returning to their respective clubs.
But Ronnie Bull will be offered a week-to-week deal over the summer and Andy Frampton is considering a further 12 month contract at Griffin Park.
Bees boss Martin Allen says the club will operate without a reserve team next season.
"After consultation with my staff, I plan on having a much reduced playing squad for my challenge to win as many games as possible," Allen said.
"We will run as a club with a first team and an under-18 team.
"If I struggle for players the under-18 boys will have to step up and step forward and I will also have the option of bringing in loan players."