Ricky Sbragia has been appointed first-team coach at Bolton after his successful spell with Manchester United's reserves.
Sbragia brought through Kieran Richardson and Darren Fletcher
The 49-year-old Scot has taken United's reserves to four trophies since arriving from Sunderland in 2002.
"I am delighted with the appointment of Ricky," Bolton boss Sam Allardyce told the club website.
"He is one of the best coaches in the country and will add more diversity to our backroom staff."
Sbragia's departure from Old Trafford means that current Under-19s coach Brian McClair is in line to take over United's reserves on a temporary basis.
The Red Devils scrapped one of their reserve sides during the summer and, with Ferguson allowing a number of young players to continue their development on loan at other clubs, Sbragia has decided that his future lies elsewhere.
McClair was due to replace Les Kershaw as United's academy chief in the summer.
Sbragia has been widely credited with developing Darren Fletcher and Kieran Richardson into full internationals.
"From a coaching point of view, he is very knowledgeable and will bring great experience and expertise in the technical and tactical approach to our coaching needs," added Allardyce.
"He has done exceptionally well at Manchester United in bringing through young players and that is one of the key areas we want him to develop at the club over a long period of time."