"I wouldn't want to put a great deal of pressure on him but, in terms of natural talent and strength and ability to go past players, I think he's got it all. The rest is up to him."
The manager did add a note of caution over the player's development, with Gabriel Agbonlahor, John Carew, Emile Heskey and Ashley Young all established regulars.
But O'Neill believes Delfouneso - who has made 14 appearances so far - has what it takes to make a lasting impact at Villa Park.
"I have seen a few players in the past with great, great talent disappear at 21, 22 but I don't think that's in his nature," he added.
"He really wants it and I think he has that determination about him. The football club will see the benefits in the next few years."
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