"Fabregas and Van Persie are due to come back on 5 August and from then on we will see how much build-up work is needed physically and as well how they have recovered mentally from the World Cup," added the Gunners boss.
"They might be short for the first game [of the season] but I don't know, that will depend on the fitness work they have done during the holiday."
However, Wenger said that he expects Denilson and Abou Diaby to be fit for Arsenal's final pre-season match, against Legia Warsaw on 7 August.
Although Johan Djourou suffered a hamstring injury in the 4-0 win over SC Neusiedl 1919 on Tuesday and Tomas Rosicky missed the match with a groin problem but Wenger has eased concerns over both players.
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