Arsenal won 2-1 at Liverpool on 13 December before taking on Burnley at Turf Moor on Wednesday, during which they lost Cesc Fabregas to a hamstring injury that will keep him out of the next match at least.
"For sure, (the fixture organisers) have never played football, organising midweek games in a week when you have a Europa League programme," said Wenger.
"We have some teams who do not play at all. We play Sunday and Wednesday away and at home on Saturday against Hull, who have not played all week."
But the Premier League has insisted that unavoidable fixture congestion affects different clubs at different times.
This page is best viewed in an up-to-date web browser with style sheets (CSS) enabled. While you will be able to view the content of this page in your current browser, you will not be able to get the full visual experience. Please consider upgrading your browser software or enabling style sheets (CSS) if you are able to do so.