Croatian striker Eduardo returned to the squad for the first time since breaking his leg almost a year ago, while young Mexican forward Carlos Vela has struggled to force his way into the first team.
But Gunners boss Arsene Wenger, who replaced the Togolese with Nicklas Bendtner at White Hart Lane, is confident his forwards can fill the void.
"Adebayor is out for three weeks with a hamstring," Wenger said.
"We have Carlos Vela, we have Nicklas Bendtner, we have Eduardo we have Andrey Arshavin and we have Robin van Persie. We have plenty of strikers.
Adebayor has already missed a month of the season through injury after damaging his knee at Stoke at the beginning of November.
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