Arsenal boss Arsene Wenger has been hit by the news that Freddie Ljungberg, Emmanuel Eboue and Julio Baptista are all facing spells out through injury.
"Freddie has a calf injury, Emmanuel will miss three to four weeks with a medial knee ligaments injury and Julio has a hamstring problem," said Wenger.
"Unfortunately when you have so many players away on international duty you can have some bad news."
However William Gallas is set to be fit for Saturday's game against Watford.
Wenger also had some positive news on the progress of Philippe Senderos and Gael Clichy, who have yet to figure in the first-team this season.
"They are making good progress, but I do not know when they will be in the team," added the Frenchman.
"They could be in the squad for one of the next two games - but they are still a little bit short of match fitness really."