Arsenal midfielder Alexander Hleb is out for up to eight weeks after picking up a knee injury on international duty for Belarus.
Hleb, 24, was injured against Scotland and joins Thierry Henry, Robin van Persie, Sol Campbell, Ashley Cole and Gilberto on the sidelines.
"Hleb will be out for six to eight weeks," confirmed Arsenal manager Arsene Wenger.
"He is due to have surgery on his knee on Friday."
Wenger added: "I can't remember having injuries like this before but it's not a crisis.
"We have lost many players over the break when we should have come back refreshed," said Wenger.
"For some it is a question of days, and others - like Ashley Cole and Hleb - it is a matter of six to eight weeks."
Hleb has been one of Arsenal's most impressive performers so far this season after joining for £10m from Stuttgart during the summer.