Arsenal manager Arsene Wenger has been charged with improper conduct for his comments after his team's 2-0 loss to Manchester United last month.
The Football Association charge relates to his remarks about striker Ruud van Nistelrooy after the game at Old Trafford on 24 October.
Wenger has been given until 23 November to respond to the charge.
The FA will not take formal disciplinary action on any other matters related to the match.
United's win ended Arsenal's English top-flight record of 49 consecutive league games unbeaten.
And Wenger was highly critical of referee Mike Riley, who awarded a penalty to United after Wayne Rooney went down under a challenge from Sol Campbell.
Wenger's comments and an incident in the tunnel, which led to United boss Alex Ferguson allegedly being hit with food thrown by an Arsenal player, were subjects of FA investigations.
Van Nistelrooy's tackle on Ashley Cole was also studied by the FA, with the result being a three-match ban for the Dutchman.
But it is Wenger's comments about the United striker that have landed him in trouble.
"We know how Ruud van Nistelrooy behaves," Wenger said. "He can only cheat people who don't know him well."
The FA has also written to both Arsenal and United, requesting a meeting with their representatives and the Premier League.
The moved is designed to try to avoid any repeat of the adverse publicity that surrounded the game.