A first-half hat-trick from Richard Offiong blew Dunfermline away and stretched the Accies' lead at the top of Division One.
The striker's first goal came from the penalty spot after Sol Bamba brought down David Graham.
The second arrived when Brian Easton rounded off a 50-yard run with a neat pass for Offiong to tap in.
Graham's cross was then converted by Offiong for his first senior hat-trick and his 18th goal of the season.
Hamilton Accies: Halliwell, Parratt, Easton, Mensing (Stevenson 83), Elebert, Swailes, Graham, McArthur (McCarthy 50), Offiong (Waterworth 81), Neil, Gilhaney. Subs Not Used: Grady, Cerny.
Booked: Parratt, Graham, Elebert.
Goals: Offiong 13 pen, 34, 43.
Dunfermline Ath: Gallacher, Woods, Scott Morrison, Simmons (Phinn 46), Wilson, Bamba, Harper, Glass, Burchill, Crawford (McManus 66), Burte (Owen Morrison 74). Subs Not Used: Howie, Murdoch.
Booked: Phinn, Wilson, McManus, Harper.
Ref: S Finnie
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