Airdrie United took advantage of some sloppy defending to open up a four-goal lead in the opening half-hour.
Stephen McKeown scored a penalty and Allan Russell shot powerfully home as the home side dithered.
Russell beat an attempted offside trap to score his second, while Kevin McDonald knocked the fourth goal past the advancing Gary O'Connor.
Danny Swanson fired home a second half penalty and set up Iain Diack to lash in a second goal for the home team.
Berwick Rangers: O'Connor, Staunton, Noble, Bolochoweckyj, Jordan Smith (Fraser 45), Thomson, Davison (Swanson 55), Greenhill, Diack, Little (Gemmill 60), McMullan. Subs Not Used: McLeish, Flockhart.
Booked: Thomson, Bolochoweckyj, Little, Swanson, Staunton.
Goals: Swanson 56 pen, Diack 66.
Airdrie Utd: Robertson, McKenna, Smith, Donnelly, Smyth, McDonald, Prunty, McKeown (Brady 89), Russell, Noble (Watt 68), McDougall. Subs Not Used: McKee, Craig, Hollis. Booked: McDonald, McKeown.
Goals: McKeown 2 pen, Russell 15, 25, McDonald 26.
Ref: C Boyle