Ten-man Queen of the South held out to salvage a draw with Hamilton, after taking an early lead and then going a player down just after the interval.
John O'Neil scored from the penalty spot after nine minutes after being brought down by goalkeeper Dave McEwan.
The Dumfries side looked the more promising until Willy Gibson was red carded for a second bookable offence.
Hamilton immediately pressed and Richard Offiong snatched the equaliser 13 minutes from time.
Queen of the South: Hinchcliffe, Henderson, Lauchlan, Jim Thomson, Paton, Scally, Moon (Callaghan 56), O'Neill (Robertson 90), Gibson, Weir (MacKenzie 65), Barrowman. Subs Not Used: Scott, Andy Thomson.
Sent Off: Gibson (52). Booked: Gibson. Goal: O'Neill 9 pen.
Hamilton Accies: McEwan, Parratt (Gilhaney 46), Sharp, Elebert, Easton, Wilson, McLeod, McArthur, Neil, Wake, Winters (Offiong 46). Subs Not Used: McCarthy, Gibson, Jellema.
Booked: Wilson, Wake. Goal: Offiong 77.
Ref: M Tumilty