Hibs were then dealt a massive blow to their ambitions when Fletcher was given a straight red card for a clumsy tackle on Berra.
With the Easter Road side reeling from the ordering off, Hearts made the numerical advantage count in ruthless fashion.
Driver was released in space on the left and his centre was met by Nade, who slotted the ball into an empty net with Hibs keeper Yves Ma-Kalambay, and the rest of the Hibs defence, posted missing.
Early in the second half Hearts were almost gifted a second goal in bizarre fashion.
Lee Wallace's shot was deflected into the path of Hibs defender David van Zanten whose misjudged pass-back was heading for the goal until substitute keeper Grzegorz Szamotulski stopped it with his outstretched foot.
Hearts dominated possession but, with their old rivals battling bravely, the Jambos struggled to create any meaningful chances.
After a lull in the frantic proceedings the previously silent home support found their voices and began to roar on their depleted side, with left-back Ian Murray typifying Hibs' fighting spirit.
But goal-scoring chances were few and far between in the last quarter, with meaty challenges taking precedent over pretty football, and Hearts again wrested back control of the game.
Szamotulski made saves from Nade and Driver before Glen sealed victory in the dying moments when he raced onto Christos Karipidis' defence-splitting pass ahead of the Polish keeper and rolled the ball into the empty net.
Hibernian: Ma-Kalambay (Szamotulski 46), van Zanten, Hogg, Jones, Murray, Johansson (O'Brien 66), Bamba, Rankin, Stevenson, Fletcher, Riordan (Nish 66). Subs Not Used: Yantorno, Chisholm.
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