Last season's runners-up Gretna swept aside First Division rivals Clyde at Broadwood to reach the last 16 of the Scottish Cup.
David Graham fired the visitors in front with a low shot three minutes before the interval.
And it was a great run from Graham that set Eric Paarpalu up for a clinical finish on 70 minutes.
Colin McMenamin claimed his 20th goal of the season after a good move involving Graham and Gavin Skelton.
Clyde: Hutton, McGregor, Malone, Higgins, Harris, Masterton, Bryson, O'Donnell, Arbuckle, Imrie, Williams (Bradley 69). Subs Not Used: Ferguson, MacLennan, Hunter, Chrie. Booked: Higgins. Gretna: Main, Townsley, Grainger, Jenkins, Canning, Innes, Paarpalu, McGill (Bingham 76), McMenamin, Graham (Berkeley 82), Skelton. Subs Not Used: Birch, Barr, Fleming. Booked: Paarpalu. Goals: Graham 41, Paarpalu 69, McMenamin 76. Att: 1,378 Ref: J Underhill