Queen of the South held off a threatened fightback by Division One rivals Clyde to move comfortably into the second round of the CIS Cup.
Goals from John O'Neill, Murray Henderson and Graham Weir had Queens in the driving seat by the 32nd minute.
Douglas Imrie pulled a goal back two minutes before the break, but O'Neill's second killed the tie stone dead.
Clyde dominated the second half and scored a deserved second thanks to Stephen O'Donnell's penalty.
Queen of the South: Corr, Lauchlan, Henderson, Jim Thomson, Paton, McKenzie, Burns, O'Neil (Henry 65), Scally, Weir (Andy Thomson 69), O'Connor (Mullen 65).
Subs Not Used: Scott, Robertson.
Booked: O'Neil, Lauchlan.
Goals: O'Neil 8, Henderson 17, Weir 32, O'Neil 45.
Clyde: Cherrie, McGregor, Higgins, Harris, Michael McGowan (McKenna 87), Malone, McHale, Bryson, O'Donnell, Arbuckle (Bradley 83), Imrie.
Subs Not Used: MacLennan, Hunter, Scott.
Booked: Higgins, Harris.
Goals: Imrie 43, O'Donnell 52 pen.
Ref: W Collum