New Wales Under-21 coach Glyn Hodges has named his first squad for a friendly match in Latvia on 18 August.
Among 12 uncapped players are new call-ups Peter Gilbert of Plymouth and Kaiserslautern's Dylan Hughes.
Both have Welsh fathers, with defender Gilbert a regular in Plymouth's side, while Canadian-born Hughes, 19, plies his trade as a striker in Germany.
Hughes used to be a Newcastle youth player and was first spotted by former Magpies skipper Gary Speed.
Hughes returned to Canada after leaving St James Park and then tried his luck in Germany, where he has had regular reserve team football.
Comparisons will be drawn with England midfielder Owen Hargreaves, another Canadian-born player with one Welsh and one English parent who made his name at a Bundesliga club.
Hargreaves broke through from the youth ranks at Bayern Munich and could have chosen to play for Wales, Germany or his native Canada before opting for England.
Wales U21 squad to play Latvia in Riga, 18 August:
Coates (TNS), Price (Ipswich), Worgan (Rushden & Diamonds), Duffy (Portsmouth), Gilbert (Plymouth), S Jones (Swansea), Morgan (Wrexham), Parslow (Cardiff), Spender (Wrexham), M Jones (Wrexham), Davies (Bangor), Fish (Cardiff), Fowler (Huddersfield), Pipe (Notts Co), Tolley (Shrewsbury), Vaughan (Crewe), Birchell (Arsenal), Caliste (Man
Utd), Fleetwood (Cardiff), Hughes (Kaiserslautern).