Wigan were beaten by Manchester United in the showpiece and Sir Alex Ferguson's men, who battled to a 3-2 win against Wolves on Tuesday, will look to take a step closer to Wembley once more when they travel to Upton Park.
West Ham claimed an extra-time victory over Stoke to reach this stage but they are currently bottom of the Premier League and have a poor recent record against United - losing each of their last six meetings, with just one goal scored and 17 conceded.
For Birmingham, who edged past Brentford on penalties, and Aston Villa it is a chance to renew their fierce local rivalry after this Sunday's Premier League meeting.
Villa, 2-1 extra-time winners over Burnley, have won each of the last six derbies and four of the six League Cup matches between the pair.
Following their 4-1 win at Leicester, a trip to Portman Road awaits for 1966 winners West Brom.
Ipswich have won just one of their last six Championship games but they proved too strong for Northampton in the fourth round and will be keen to reach a first League Cup semi-final since 2001.
Arsenal v Wigan Birmingham v Aston Villa West Ham v Manchester United Ipswich v West Brom
Ties to be played in the week commencing 29 November
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