Man Utd beat Spurs in the Carling Cup final last season
Carling Cup holders Manchester United will host Tottenham in the quarter-finals, while Manchester City will be at home to Arsenal.
Chelsea face a trip to Blackburn in the last eight, while Portsmouth will play Aston Villa at Fratton Park.
The game between United and Spurs will be a repeat of last year's final when Sir Alex Ferguson's side beat the White Hart Lane club on penalties.
The quarter-final matches will take place week beginning 30 November.
City beat Arsenal 4-2 earlier this season in controversial circumstances and their tie could again pit Emmanuel Adebayor against his former Gunners team-mates.
Adebayor was banned for a stamp on Robin van Persie and fined for his celebration after scoring in City's win.
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