Wycombe's reward for upsetting Charlton in the Carling Cup is a semi-final against Premiership champions Chelsea.
The League Two outfit will host Jose Mourinho's side on 9 or 10 January, with the away leg two weeks later.
The other last four encounter will see Tottenham take on north London rivals Arsenal.
Spurs will host the first leg on 17 January and will travel to the Emirates Stadium one week later.
606 DEBATE: Give your thoughts on the draw
Wycombe beat Premiership strugglers Charlton in the quarter-finals thanks to a goal from Jermaine Easter.
Manager Paul Lambert was delighted to draw Chelsea.
"It's a terrific tie. Regardless of who we got it was always going to be tough. It's a terrific achievement and we've earned the right to be there," he said.
"It's a massive game for us against a team that can win the Champions League, never mind the Premiership."