Southend will play host to defending champions Manchester United in the fourth round of the Carling Cup.
In all-Premiership match-ups, Aston Villa travel to Chelsea, Arsenal face an away game against Everton, while Watford welcome Newcastle.
In other ties, Tottenham entertain Port Vale, Charlton visit Chesterfield, Liverpool travel to Birmingham and Notts County host Wycombe Wanderers.
All matches are scheduled to be played on 7-8 November.
Draw for the Carling Cup fourth round:
Notts County v Wycombe
Tottenham v Port Vale
Birmingham v Liverpool
Chelsea v Aston Villa
Watford v Newcastle
Chesterfield v Charlton
Southend v Man Utd
Everton v Arsenal