The Railway Stand at Windsor Park has been closed down after being deemed unfit for use by Fire Authority and Health and Safety officials.
A smoking ban comes into effect for the game against Sweden
The structure, which held a few hundred people, will now not be occupied during Northern Ireland international matches.
The move comes amid fears that the stadium may not be passed for use after this month's home game against Sweden.
The South Stand was recently deemed a fire risk and the North Stand has suffered roof structural damage.
Smoking has been banned in Windsor Park stands for all future international games.