USA 2-0 Wales
Donovan was the star attraction for the home crowd
Matthew Jones suffered a miserable night as Wales slumped to defeat against the USA in San Jose.
The Leicester City defender gave away a penalty just before half-time, and was sent off after picking up a second yellow card for a deliberate handball moments into the second half.
Landon Donovan coolly converted from the spot in the 40th minute, and Eddie Lewis scored from distance on the hour to give the home side a deserved victory.
The defeat brought to an end a sequence of 10 games without defeat in an impressive season for Wales.
Welsh boss Mark Hughes selected an inexperienced side in the absence of John Hartson, Ryan Giggs, Craig Bellamy and Robbie Savage among others.
But the USA were without Brad Friedel, John O'Brien and Brian McBride, with Claudio Reyna starting on the bench.
However, it was the home side who dominated from the opening moments, with youngsters Donovan and Bobby Convey controlling midfield.
After several missed chances Jones finally handed the USA a golden opportunity when he clattered into the back of Jovan Kirovski to concede the penalty.
Hopes of a second-half comeback were dealt a blow when the Leicester man stuck out an arm to stop the charging Convey going past him in the 48th minute, and a red card followed.
Convey almost doubled the advantage when clean through soon after but substitute 'keeper Darren Ward made a superb save.
Eddie Lewis wrapped up the win for the USA
Disappointment followed for Ward moments later, however, when a poorly struck Lewis shot from distance sneaked under the keeper's dive and into the bottom corner.
With only 10 men it was always going to be a struggle for Wales, and the closest they came was a blistering effort from John Oster.
But there was far more action at the other end, with both Donovan and Earnie Stewart stretching the Welsh defence.
USA: Rimando, Suarez (Petke, 78), Brown, Agoos, Vanney, Mulrooney, Stewart (Lagos, 83), Convey (Ching, 75), Lewis, Donovan, Kirovski (Eskandarian, 89).
Wales: P Jones (Ward, 46), M Jones, Vaughan, Melville, Williams, Pembridge (Robinson, 79), Oster (Pipe, 70), Johnson, Davies, Koumas, Taylor.
Referee: Benito Archundia Tellez (Mexico).