Berti Vogts' preparations to face Germany next month have suffered a blow after defenders Lee Wilkie and Andy Webster withdrew from Tuesday evening's Future Team international.
Lee Wilkie (left) was criticised for recent performances
Vogts had been hoping to give Wilkie a boost to his confidence following high-profile nightmare displays against Celtic and Rangers by playing him against Northern Ireland at Firhill Stadium.
And the German was anxious to give Webster more international experience after the Hearts defender made his Scotland debut against Austria last month.
But both players withdrew through injury on Monday night.
Rangers' Maurice Ross was drafted in as a late replacement and will start on the bench.
Newcastle United's Caldwell brothers, Gary and Steven, are therefore paired at the heart of the defence.
Vogts named an attacking line-up, with Sunderland's Kevin Kyle and Motherwell's James McFadden being joined by experienced West Ham United forward Don Hutchison.
The Futures side was designed to give fringe players the opportunity to achieve international experience, but Vogts has this time used it as a way of preparing for the match against Germany.
He was keen to especially help keep English-based players match fit as their league season as now ended.
Seven of the 11 starters could be considered first-choice players in Vogts' main side.
Irish League players Gareth McAuley and Andy Smith will be in Northern Ireland's starting line-up, but FA Cup final star Chris Baird will be missing.
Baird has been excused following his surprise inclusion in the Southampton side beaten 1-0 by Arsenal at the Millennium Staduim on Satuday.
Wrexham's Jim Whitley is also absent because of a family illness.
Manager Sammy McIlroy said he planned to use the game to have a good look at some of the players on the fringe of his full international squad ahead of the friendly in Italy and European qualifier against Spain.
That includes the top players in the Irish League and the NI boss revealed he planned to start with Coleraine defender McAuley and Glentoran's top-scoring striker Smith.
Scotland: Paul Gallacher (Dundee United), Graham Alexander (Preston North End), Gary Naysmith (Everton), Christian Dailly (West Ham United), Steven Caldwell (Newcastle United), Gary Caldwell (Newcastle), Paul Devlin (Birmingham City), Brian Kerr (Newcastle), Kevin Kyle (Sunderland), Don Hutchison (West Ham), James McFadden (Motherwell(. Subs: Kenny Arthur (Partick Thistle), Andy Gray (Bradford City), Maurice Ross (Rangers), Darren Fletcher (Manchester United), David Noble (West Ham), Simon Lynch (Preston), Derek Soutar (Dundee).
Northern Ireland 'B': Tom Evans (Scunthorpe United), Michael Duff (Cheltenham Town), Stephen Craigan (Partick Thistle), Gareth McAuley (Coleraine), Grant McCann (Cheltenham Town), Steve Jones (Crewe Alexandra), Danny Griffin (Dundee United), Tommy Doherty (Bristol City), Stuart Elliott (Hull City), Andy Kirk (Hearts), Andy Smith (Glentoran). Subs: Elliott Morris (Glentoran), Shaun Holmes (Wrexham), Wayne Carlisle (Bristol Rovers), Rory Hamill (Coleraine), Gary Hamilton (Portadown).