The Cardiff City Stadium has held just 10 Cardiff City games since it opened
Wales will play Scotland in a friendly in the first international at the new Cardiff City Stadium on 14 November.
Scotland were the first international visitors to Cardiff City's old ground, Ninian Park, in March 1911.
The Welsh FA are also expected to use the new ground for competitive fixtures in the forthcoming 2012 European Championship qualifying campaign.
The national team look set to leave Cardiff's Millennium Stadium and go on the road for matches.
The 14 November date is the international date set aside for the 2010 World Cup play-off games.
Rob Earnshaw celebrates his hat-trick when Wales last hosted Scotland
But, as both Wales and Scotland can no longer qualify for South Africa, rival managers John Toshack and George Burley have utilised the available date to play each other.
A Scottish club helped Cardiff officially open the new Cardiff City Stadium as Celtic were the first pre-season visitors to the £50m, 26,000-capacity arena before the opening league match with Scunthorpe in August.
The Scots will probably have more Cardiff City players playing at their home club ground than Wales.
Scottish internationals David Marshall, Ross McCormack, Gavin Rae, Chris Burke and Kevin McNaughton all play for the Bluebirds, while Wales usually boast just one Cardiff player, Joe Ledley, in their squad.
The Scots are Wales' oldest international footballing rivals as their first meeting was a 4-0 defeat on 25 March, 1876 in Glasgow.
Scotland have beaten the Welsh 60 times in their 103 meetings with Wales winning just 20 - although a Rob Earnshaw hat-trick at the Millennium Stadium ensured Wales won the last encounter 4-0 in February 2004.
The Scots have infamously quashed Wales' major final qualifying dreams twice, preventing the Welsh qualifying for the 1978 and 1986 World Cup finals.
The never-to-be-forgotten Joe Jordan handball incident of their 1977 showdown will forever be painfully etched in the memory of Welsh football fans when the Scottish striker won a penalty in the final 12 minutes of their final qualifier.
Replays clearly show Jordan deliberately handled the ball from Asa Hartford's long throw into the Welsh box and not Wales defender David Jones.
But French referee Robert Wurtz awarded a crucial penalty kick which Don Masson scored and Welsh hopes were dashed as Scotland went on to win 2-0.
Wales then needed to beat Scotland at Ninian Park in September 1985 to qualify for a play-off with Australia for a place at the 1986 World Cup in Mexico.
But, despite Mark Hughes' goal, Wales drew 1-1 and Scotland ultimately qualified on a fateful night when Scottish manager Jock Stein suffered a fatal heart attack in the Ninian Park dugout.
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