Spain have never won the World Cup and their best performance to date came in 1950 when they finished fourth.
At the last World Cup in Germany, Spain topped their group to progress but then lost 3-1 to France in the second round.
However, many will expect Spain to progress much further in South Africa.
Coach del Bosque inherited a side that predecessor Luis Aragones led to Euro 2008 glory - their first major title since 1964.
The former Real Madrid boss Del Bosque began his tenure in impressive fashion, becoming the first international manager to win 10 successive games from his debut.
The run came to a surprising end against the United States at the 2009 Confederations Cup semi-finals, but during that competition Spain claimed the world record of 15 consecutive wins.
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