"It's given me a chance and hopefully I'll take it. The bar is raised again and it is up for me to step up.
The 27-year-old earns his first involvement in Trapattoni's reign after impressing in Stoke's Premier League survival campaign.
Preston duo Nolan and St Ledger are also included along with Coventry City striker Best but there is still no place for Sunderland midfielder Andy Reid.
The squad will be reduced to 22 for the World Cup qualifier against Bulgaria in Sofia the following weekend.
Alex Bruce, Damien Delaney, Steve Finnan, Darren O'Dea and Noel Hunt are missing from the squad initially named for the last two qualifiers against Bulgaria and Italy.
Republic of Ireland squad: Shay Given (Manchester City), Dean Kiely (West Brom), Kieren Westwood (Coventry), Eddie Nolan, Sean St Ledger (both Preston), John O'Shea (Manchester United), Kevin Foley (Wolves), Paul McShane (Sunderland), Richard Dunne (Manchester City), Stephen Kelly (Birmingham), Kevin Kilbane (Hull); Aiden McGeady (Celtic), Damien Duff (Newcastle), Darron Gibson (Manchester United), Glenn Whelan (Stoke), Keith Andrews (Blackburn), Liam Miller (QPR), Stephen Hunt (Reading), Andy Keogh (Wolves), Liam Lawrence (Stoke); Caleb Folan (Hull), Robbie Keane (Tottenham), Shane Long (Reading), Leon Best (Coventry).
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