And in the early stages the gulf in class was obvious, with Stuart Pearce's side dominating possession and Wales trying, unsuccessfully, to get their playmaker Ramsey on the ball.
Following a spell of heavy pressure, it was no surprise when England took the lead on 13 minutes but the manner of their goal was disappointing for Wales.
Ramsey needless fouled Adam Johnson on the edge of the area and, although Huddlestone struck his free-kick firmly, Owain Fon Williams' wall was not sturdy enough and he also reacted slowly as the ball flashed past him and into the net.
Initially, Wales created nothing in response and England's defence continued to look comfortable.
But that all changed when Ramsey levelled with a goal out of nowhere on 24 minutes - the £5m Arsenal midfielder picking up the ball 30 yards out and taking a touch before sending a shot rocketing into the top corner.
Aaron Ramsey lets fly with his equaliser for Wales
And the 17-year-old rocked England again five minutes later when he ran at their defence and slipped an inch-perfect pass through to Church, who coolly lifted the ball over the on-rushing Joe Hart for his third goal of the tie.
That brought Wales level at 4-4 on aggregate and although England still had the lead on away goals they still had work to do.
But Wales' fragility at set-pieces meant the home side did not have to wait long to regain their advantage.
After 35 minutes, another free-kick - this time whipped in from the right by Jamie O'Hara - was met by Steven Taylor and bounced off Vokes into the net.
The match settled down after the break, with both sides seemingly aware of the importance of the next goal.
But Huddlestone's dismissal gave Wales the impetus and, with Ramsey orchestrating the play, they pushed forward with real purpose.
By now, England were on the back foot, with substitute Fraizer Campbell cutting an isolated figure up front.
Pearce's men defended stubbornly, however, and Wales' last chance came and went when Vokes' low shot crashed against the post.
England U21: Hart, Wheater, Mancienne, Steven Taylor, O'Hara, Noble, Huddlestone, Cattermole (Muamba 31), Milner, Johnson, Agbonlahor (Campbell 46). Subs Not Used: Andrew Taylor, Heaton, Cranie, Derbyshire, Lallana.
Sent Off: Huddlestone (66).
Goals: Huddlestone 13, Vokes 35 og.
Wales U21: fon Williams, Eardley, Wiggins, Blake, Jacobson, Collison, King (Bradley 60), MacDonald (Adams 84), Ramsey, Church, Vokes. Subs Not Used: Taylor, James, Basey, Brown, Allen.
This page is best viewed in an up-to-date web browser with style sheets (CSS) enabled. While you will be able to view the content of this page in your current browser, you will not be able to get the full visual experience. Please consider upgrading your browser software or enabling style sheets (CSS) if you are able to do so.