Thirty-seven-year-old Kiely will be earning his ninth cap while Stephen Kelly and Paul McShane will join Dunne and debutant Delaney in defence.
Liam Miller and Whelan have been selected in central midfield, flanked by Damien Duff on the right and Stephen Hunt on the opposite side.
Captain Keane will operate in attack alongside Kevin Doyle.
Darren O'Dea is still expected to link up with the Republic squad ahead of Saturday's game but McGeady will miss the game and he is also unlikely to feature against Colombia at Craven Cottage on Thursday.
Twenty-six-year-old Delaney will make his Republic debut after earning his first call-up to the senior squad.
Delaney joined QPR in January after an impressive couple of years at Hull City.
I had 10 days' break and no matter what I do in that 10 days, that's all personal stuff to me
Whelan has been capped at all underage levels for the Republic and he has also acted as skipper in several of the grades.
The Dubliner achieved promotion to the English Premier League last month with Stoke City, the club he joined from Sheffield Wednesday in January.
O'Shea has not been named in the starting line-up and may not feature at all after Manchester United's Champions League triumph.
Republic captain Keane and Dunne were excused from the recent training camp in Portugal and the Tottenham striker defended his absence from the trip.
"I spoke with the manager and Liam Brady and the club wanted me to have 10 days' break," said Keane.
"The club was supposed to go to South Korea and I didn't have to go on that, but then it was cancelled at the last minute, so they wanted me to rest because I have played so many games this season.
"I had 10 days' break and no matter what I do in that 10 days, that's all personal stuff to me."
Republic of Ireland: Kiely (West Brom), Kelly (Birmingham City), Dunne (Manchester City), McShane (Sunderland), Delaney (QPR), Duff (Newcastle United), Miller (Sunderland), Whelan (Stoke City), Hunt (Reading), Keane (Tottenham Hotspurs), Doyle (Reading).
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