Yossi Benayoun will miss Israel's Euro 2008 qualifier with Russia on 17 November, dealing England's hopes of reaching the finals a major blow.
Benayoun has scored 13 goals in 53 games for Israel
England need Israel to at least draw in Tel Aviv if they are to stand a chance of finishing second in Group E and Benayoun is the Israelis' key player.
The Israel captain was injured in Liverpool's 2-0 win over Fulham.
And the midfielder has been ruled out for three weeks after a scan on Sunday revealed an adductor tear.
Benayoun, who had already cancelled his flight to join up with his international team-mates, was one of only two players in Israel's squad to play in the Premier League.
The other is Chelsea defender Tal Ben Haim, while QPR striker Ben Sahar is also in the squad, which includes Argentine-born Borussia Moenchengladbach striker Roberto Colautti, who has recovered from injury.
Liverpool star Benayoun, 27, has an impressive international goalscoring record, having scored 13 goals in 53 games.
If England fail to qualify for the finals it will be the first time they have missed out on a major tournament since the 1994 World Cup.
Israel squad to face Russia:
Goalkeepers: Dudu Aouate (Deportivo Coruna), Nir Davidovich (Maccabi Haifa), Liran Strauber (Maccabi Netanya).
Defenders: Tal Ben Haim (Chelsea), Shimon Gershon (Beitar Jerusalem), Yoav Ziv (Beitar Jerusalem), Dekel Keinan (Maccabi Haifa), Eyal Meshumar (Maccabi Haifa), Avi Strul (Maccabi Netanya), Dedi Ben Dayan (Maccabi Netanya), Yuval Shpungin (Maccabi Tel Aviv).
Midfielders: Gal Alberman (Beitar Jerusalem), Aviram Baruchyan (Beitar Jerusalem), Tamir Cohen (Maccabi Netanya), Moshe Ohayon (Winterthur), Maor Buzaglo (Bnei Sakhnin), Ravid Gazal (Maccabi Tel Aviv).
Strikers: Roberto Colautti (Borussia Monchengladbach), Ben Sahar (Queens Park Rangers), Elyaniv Barda (Genk), Omer Golan (Maccabi Petah Tikva), Barak Yitzhaki (Beitar Jerusalem), Amit Ben Shushan (Beitar Jerusalem).