Barnsley's players celebrate their amazing win at Anfield on Saturday
Championship side Barnsley have been rewarded for their stunning FA Cup win at Liverpool with a quarter-final tie at home to holders Chelsea.
League One side Bristol Rovers have been drawn at home against West Brom and in the only all-Premier League tie, Manchester United entertain Portsmouth.
In the other sixth-round contest, Championship side Cardiff City travel to Premier League Middlesbrough.
The games will be played on the weekend of 8 and 9 March.
Barnsley boss Simon Davey admitted the Tykes had their dream draw after being paired with Avram Grant's Chelsea.
It's typical that we drew another Premier League team
Manchester United boss Sir Alex Ferguson
"It is a fantastic draw and a fantastic achievement for us to be here - and now we have a glamour tie as our reward," said Davey.
"We have a world-renowned team with some of the best players in the world coming here and it is one to look forward to.
"We have to make sure that this place is a cauldron for them and I am sure it will be packed. Hopefully we can put on a show for our supporters."
Bristol Rovers midfielder Chris Lines admits he cannot wait for the club's first FA Cup quarter-final since 1958.
"All the lads will be happy with a home draw and so will the club. We are all looking forward to it," Lines told BBC Radio 5 Live.
"The pitch isn't in the best condition but it's a real leveller when teams from higher leagues come down here - we've proved that against Fulham and Southampton.
"We've had some experience of playing at Wembley in last season's play-offs but this would be even more of a fairytale to get to an FA Cup semi there."
Manchester United have now been drawn against Premier League opposition in their last 11 FA Cup draws - their 3-0 win at Wolves on 20 January 2006 the last time they played a lower league side in the competition.
"It's typical that we have another Premier League team," said Ferguson. "But it's a home draw, so it doesn't matter who you get.
"The good thing about the FA Cup is that the opposition bring an increased number of supporters, which makes for a great atmosphere."
Full draw for FA Cup quarter-finals:
Middlesbrough v Cardiff City
Manchester United v Portsmouth
Bristol Rovers v West Brom
Barnsley v Chelsea
Matches to be played on the weekend of 8 and 9 March.