Chelsea and Manchester United have avoided each other in the draw for the FA Cup quarter-finals.
Manchester United will play Middlesbrough after both came through tricky replays.
Chelsea face Tottenham at home while Blackburn's win over Arsenal means they will host Manchester City in the ties to be played on 10 and 11 March.
Ian Holloway's Plymouth meet Watford at Home Park in a repeat of the 1984 semi-final, won by the Hornets.
"We're delighted with anybody at home," Holloway told BBC Five Live. "They've got the travelling and our fans can come out and celebrate.
"All I want to do is give them a hell of a game.
"Watford will get themselves out of where they are in the league and their team is epitomised by never ever giving up."
Watford forward Tommy Smith believes victory at Argyle can help the club's bid for Premiership survival.
He said: "Most clubs want to avoid the bigger clubs so we're fairly pleased with the trip to Plymouth.
"We didn't play brilliantly in the last round and Ipswich gave us a tough time.
"I think the cup run has helped though. It gives you a bit of momentum that you can carry from the cup into the league."
606 DEBATE: Your FA Cup quarter-final predictions
FA Cup quarter-final draw
Middlesbrough v Manchester United
Blackburn v Manchester City
Chelsea v Tottenham
Plymouth v Watford