Southampton will meet Manchester United at home in the FA Cup quarter-finals after despatching Brentford.
Saints knocked out the Bees after a replay on Tuesday and will now take on United in a re-run of the 1976 final.
Bolton host Arsenal after their shoot-out victory over Sheffield United and Leicester will visit Blackburn, who beat Burnley in a replay on Tuesday.
Newcastle will be at home to Tottenham, who comfortably eased past Nottingham Forest in their replay on Wednesday.
The ties will be played on the weekend of 12-13 March.
Full sixth-round draw:
Newcastle v Tottenham
Southampton v Manchester United
Bolton v Arsenal
Blackburn v Leicester