New Southampton manager Harry Redknapp faces an immediate reunion with his old club Portsmouth after they were drawn together in the FA Cup fourth round.
Manchester United will entertain Middlesbrough in an all-Premiership tie after their replay win over Exeter.
Oldham's reward for beating Manchester City is a home tie with Bolton, while Yeovil will be away to Charlton.
Chelsea host Birmingham, Tottenham travel to West Brom and Liverpool's conquerors Burnley face Bournemouth.
Saints boss Redknapp was upbeat about the draw despite having to face the club he walked out on just six weeks ago.
"I've said before, I can walk away from Portsmouth with my head held high, I'm proud of what I did there and no one can take that away from me," said Redknapp.
"Maybe I'll be in for some stick, there's always some of that but we'll get on with it and it's only a game of football."
Portsmouth chairman Milan Mandaric was unhappy at seeing Redknapp leave Pompey for their bitter local rivals, but said there was no ill feeling towards his former manager.
"There's no bad feeling between me and anyone in my life," said Mandaric.
"We will have a professional approach and treat each other the way we deserve to be treated.
"But it's a great draw and we are looking forward to it. We've good confidence, a good team, good management of the team and we will be ready for that game."
There are three London v West Midlands pairings.
Tottenham travel to West Brom whilst Wolves are at Arsenal, and Birmingham boss Steve Bruce says his side have the toughest draw possible - away to Premiership leaders Chelsea.
"I'm still in shock," he said upon hearing the news.
"We've given good accounts of ourselves against Chelsea in the past and played well when we lost 1-0 at home at the start of the season - but that's the past.
"But it's the best competition in the world as far as I am concerned and we will give it our best shot."
Yeovil boss Gary Johnson said he was looking forward to playing Premiership opposition when his side visit Charlton.
"Our supporters will travel to London in their numbers," said Johnson.
"We will have a fantastic following down there, but it gives us a chance to see how we fare.
"Hopefully it'll be a terrific match. Alan Curbishley and his team have done fantastically well to stay in the Premiership for as long as they have."
FA Cup fourth round draw:
Derby v Fulham
Man Utd v Middlesbrough
Blackburn v Colchester
Chelsea v Birmingham
West Ham v Sheff Utd
Oldham v Bolton
Arsenal v Wolverhampton
Everton v Sunderland
Nottm Forest v Peterborough
Brentford v Hartlepool
Reading v Leicester
Burnley v Bournemouth
Southampton v Portsmouth
West Brom v Tottenham
Newcastle v Coventry
Charlton v Yeovil
Ties will be played on the weekend of 29 and 30 January.