Benitez rested several of his first-choice players
Defending champions Inter Milan slumped to a 3-0 Champions League defeat at Werder Bremen to add to the pressure on coach Rafael Benitez.
Benitez, whose side had already qualified for the last 16, rested several players with an eye on the Club World Cup later this month.
But the defeat meant his side finished second in Group A behind Tottenham.
"We had a few young players and they found it tough going," said Benitez, whose side are fifth in Serie A.
Inter have now lost seven times in all competitions this season - the same number of defeats as they suffered in the whole of the last campaign under former coach Jose Mourinho.
Sebastian Proedl headed Bremen, who had failed to win any of their previous matches in the tournament this season, into the lead and Marko Arnautovic, who played on loan for Inter last season, doubled the score four minutes after half-time.
Substitute Claudio Pizarro sealed their win two minutes from time after the German side twice hit the woodwork in a one-sided game.
FC Copenhagen became the first Danish side to reach the last 16 in the competition's current format.
They beat Panathinaikos 3-1 to clinch second place in Group D behind Barcelona, who ended the group stage unbeaten after a second-string team defeated Rubin Kazan 2-0.
"It's fantastic, really fantastic," said Copenhagen winger Jesper Gronkjaer. "We have written history. We fully deserved it."
Manchester United denied Valencia top spot in Group C thanks to Anderson's second-half goal which cancelled out Pablo Hernandez's opener for the Spanish side.
Schalke won Group B with a 2-1 victory at Benfica as second-place Lyon were held to a 2-2 draw by Hapoel Tel Aviv.
Group winners are kept apart in the last-16 draw, which will be held on 17 December, giving potentially easier draws against the runners-up.
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