Messi and Villa got Barcelona's campaign off to a fine start
Holders Inter Milan were involved in a thriller on their return to Champions League action as Rafael Benitez's side were held 2-2 at Dutch debutants FC Twente.
BBC Sport rounds up the action on the first Champions League proper night of the season, including a brace for last term's top scorer Lionel Messi in Barcelona's win over Panathinaikos.
Under former Liverpool boss Benitez, Inter enjoyed a rollercoaster start to the defence of their title at Michel Preud'homme's FC Twente as the Eredivisie outfit made a great start to life in Europe's premier club competition.
After Wesley Sneijder gave Inter an early lead the Dutch hit back and went ahead thanks to a brilliant Theo Janssen free-kick and a headed own goal from Diego Milito.
Samuel Eto'o spared Benitez and Inter's blushes by bagging his 20th Champions League goal before the break as it ended 2-2.
United, who made 10 changes from their 3-3 draw at Everton on Saturday, could not break down a stubborn Rangers rearguard and they also saw winger Antonio Valencia stretchered off with a serious-looking injury in the second half.
The 2006 and 2009 champions Barcelona fell behind early on at home to Panathinaikos, but they recovered to record a comprehensive 5-1 win over the Greek side.
Sidney Govou fired home from Djibril Cisse's flick to stun the Camp Nou, but Messi slotted in to level, David Villa swept in a second and Messi fired home to make it 3-1.
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