Villa starred as Valencia narrowly made it through to the last eight
David Villa's hat-trick helped Valencia progress to the Europa League quarter-finals on away goals after a thrilling 4-4 second-leg draw at Werder Bremen.
The Spanish side were held 1-1 at home in the first leg but Villa produced a stunning display to send them through.
Sergio Aguero's double in a 2-2 draw with Sporting Lisbon also put Atletico Madrid through on away goals.
Goals from Liedson and Anderson Polga gave Sporting hope, but it was not enough to see them through.
German outfit Hamburg progressed 6-5 on aggregate despite losing 4-3 at Belgian side Anderlecht.
Hamburg led 3-1 after the first leg and when Jerome Boateng grabbed a 42nd-minute opener it looked a mere formality that they would be in Friday's draw for the last eight.
But Ronmelu Lukaka and Matias Suarez gave the home side a 2-1 lead at half-time, Lucas Biglia and Mbark Boussoufa put the Belgians 4-2 up on the night before Mladen Petric ended any hopes of a stirring comeback.
Hamburg were joined in the last eight by compatriots Wolfsburg, who needed extra-time to beat Rubin Kazan.
Christian Gentner scored in the 119th minute as Wolfsburg advanced 3-2 on aggregate at the expense of the Russian side, who had Cesar Navas sent off in the extra period for a second yellow card.
Bremen were unable to make it a trio of German clubs, partly through the clinical brilliance of Villa but also their failure to convert more of their 27 shots on target.
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