Some critics have suggested Ferdinand's best days are behind him, and the criticism levels rose again in the recent 2-0 defeat by Liverpool after the defender was easily brushed aside for Fernando Torres to score the opener.
But his Scottish manager is certain the centre-half will soon recover from his injury concerns and be back to his best.
Speaking ahead of the Old Trafford clash with the Russians, the 67-year-old added: "There is no discernible depreciation in his qualities - none for me at all.
Wayne Rooney leaves hospital with baby
"Playing with injuries is not the easiest thing to do and we'll try to get that right.
"Calf injuries can be troublesome. If you don't arrest it and give it proper treatment then you can end up the way we are now, and playing in games when you are not 100% fit."
With central defensive partner Nemanja Vidic also struggling with calf problems, United are likely to start with Jonny Evans and Wes Brown who both played in Saturday's 2-0 win over Blackburn.
Following Monday's news that Wayne Rooney had become a father, striker Michael Owen could well be set for a starting place.
The 29-year-old has scored three times this season in all competitions since his summer move to United and despite the South African World Cup looming, the former Liverpool star insisted his priorities remained closer to home.
Owen focused on club not country
"England is something I don't really think about," said Owen. "It is probably something people talk about a lot more than I think about really.
"The last squad I was in was over a year ago now. I have played for England 89 times and I would love to play for England again.
"I genuinely go to bed thinking that I have got to play well the next day and win games for Manchester United, not that if I score or play well I might get picked for England."
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