Holders Valencia were sent crashing out of the Uefa Cup on penalties after blowing a first-leg advantage over Steaua Bucharest on Thursday.
Valencia lost the shoot-out 4-3 after their 2-0 away defeat in the second leg had cancelled out last week's 2-0 win
Man-of-the-match Andrei Cristea scored twice in the second half to send the match into extra time before penalties.
Meanwhile, Bundesliga outfit Schalke went of the competition after a 1-0 loss to Shakhtar Donetsk.
Julius Aghahowa scored after 21 minutes to send the Ukrainian side through, having drawn 2-2 in the first leg tie last week.
Earlier, 10-man Partizan Belgrade secured the first spot in the last 16 with a 1-0 win at Dnipro.
Substitute Miroslav Radovic scored with only three minutes remaining to allow Partizan to advance 3-2 on aggregate.
AZ Alkmaar came back from a goal down to beat Alemannia Aachen 2-1 and grab their spot in the next round.
Erik Meijer scored early for the visitors but second-half goals from Barry van Galen and Joris Mathijsen secured victory.
Auxerre pulled off one of the most memorable results in their European history as substitute Lionel Mathis' late goal secured a 3-2 aggregate win over Ajax to set up an all-French clash with Lille.
Extra-time goals from Marco Marchionni and Andrea Pisanu helped 10-man Parma turn over Stuttgart 2-0 on aggregate, despite the sending-off of Paolo Cannavaro.
Real Zaragoza had a 3-1 aggregate victory over a disappointing Fenerbahce after goals in each half from Luciano Galletti and Savio Bortolini gave them a 2-1 win in the second leg.
Ieroklis Stoltidis scored a second-half winner to lift Greek club Olympiakos past Sochaux 1-0 and
into the last 16.
They will play Newcastle, who beat Heerenveen 2-1 for a third round aggregate of 4-2.
Michel Breuer put through his own goal before skipper Alan Shearer doubled the Magpies' lead when he scored from a free-kick. Arnold Bruggink scored a late penalty consolation for the Dutchmen.
Fellow Premiership side Middlesbrough also made it through after a 2-1 win over Graz AK.
Mario Bazina stunned Boro with an early goal before strikes from James Morrison and Jimmy Floyd Hasselbaink set up a showdown with Sporting Lisbon - who beat Feyenoord 2-1 in the second leg, with goals from Da Silva Liedson and Fabio Rochemback.
Lille overcame an early bout of nerves to see off Basle 2-0, after the first
leg had ended goalless.
Benfica saw their Cup dreams ended by a CSKA Moscow side who had already done the hard part by winning the first leg 2-0 in Krasnodar. A 1-1 draw completed a 3-1 aggregate result.
Villarreal's two first-half goals against Dinamo Kiev allowed them to stroll
into the next round 2-0 on aggregate, despite playing the entire second half
with 10 men.
Substitutes Ariza Makukula and Adriano Correia scored late goals to earn Sevilla a 2-0
victory over Panathinaikos and send the Spanish team through on a 2-1 aggregate.
Uefa Cup round of 16 draw:
Middlesbrough v Sporting Lisbon
Sevilla v Parma
Steaua Bucharest v Villarreal
Lille v Auxerre
Olympiakos v Newcastle
Shakhtar Donetsk v AZ Alkmaar
Partizan Belgrade v CSKA Moscow
Austria Vienna v Real Zaragoza
*Ties to take place on 10/17 March