German second division side Alemannia Aachen provided the shock of the inaugural Uefa Cup group stage by beating high-flying French club Lille.
Second only on goal difference to Lyon in Ligue 1, Lille were second-best to the German side in the Group H game.
And on 67 minutes former Liverpool striker Erik Meijer tapped in at the far post from a Simon Rolfes cross.
Aachen only qualified for the Uefa Cup after losing the German Cup to Champions Werder Bremen.
The German side also had to play in Cologne as their own ground did not meet Uefa standards.
In the other Group H game, Alexander Kerzhakov scored a hat-trick as Zenit St. Petersburg came from behind to trounce AEK Athens 5-1 in Russia.
Asimakis Krassas gave AEK the lead, but Andrei
Arshavin equalized just before halftime, with Kerzhakov
scoring three times before Igor Denisov added a fifth.
Feyenoord took command of Group A after comprehensively beating Hearts 3-0, as Schalke 04 and FC Basle drew 1-1 in Gelsenkirchen.
Goals early in each half gave Spain's Athletic Bilbao a 2-0 win over Serie A side Parma in Group B.
Carlos Gurpegi scored on five minutes, while Asier del Horno added a second on 49 minutes.
Steaua Bucharest beat Standard Leige 2-0 after taking the lead through an Ivica Dragutinovic own goal midway through the second half, with Adrian Neaga extending the Romanian side's lead.
In Group C, Dnipro Dnipropetrovsk beat Club Brugge 3-2 in
Ukraine with two goals from Oleh Venhlinskiy.
Brugge twice came from behind to level, but just past the hour Venhlinskiy scored his second to give Dnipro the win.
In Spain striker David Villa scored two late goals to give Real Zaragoza a deserved 2-0 victory over Utrecht.
In Group D, goals from Araujo Ilan and Gregory Paisley scored to lift
French side Sochaux to a 2-0 victory over Dinamo Tbilisi in the Georgia.
Midfielder Johann Lonfat crossed for Brazilian striker Ilan
to fire in, while defender Gregory Paisley added a second before half-time heading in from a corner.
Sochaux goalkeeper Teddy Richert made a series of stunning saves in the second half to deny Tbilisi striker Levan Melkadze.
In the group's other game, Newcastle secured a last-gasp win over Greek side Panionios thanks to an Alan Shearer penalty.
Tommaso Rocchi scored seven minutes from time to salvage a point for Lazio in their Group E game with Villarreal.
The La Liga club had taken a fourth minute lead through
Jose Mari, who was sent off just before the Lazio equaliser after elbowing Giuliano Giannichedda.
Middlesbrough beat Aigaleo 1-0 in Athens in the other Group E match.
With French club Auxerre drawing 0-0 with Graz AK of Austria, Glasgow Rangers took control of Group F after Amica Wronki 5-1 away in Poland.
In Group G German club VfB Stuttgart trounced Beveren 5-1 in Belgium, with Cacau scoring twice, with Kevin Kuranyi, Philipp Lahm and Imre Szabics also getting on the scoresheet.
And Benfica defeated Heerenveen 4-2 at home with Nuno Gomes scoring twice.